Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes

Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes

Calcium phosphate ceramics like hydroxyapatite (HA) are widely used to repair and reconstruct damaged parts of the human skeleton. This material is currently available as injectable cements, granules or macroporous blocks. The most familiar materials are granule shaped ones because their conveniency...

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Main Authors: Hornez J.C., Bouchart F., Meurice E., Descamps M., Leriche A.
Format: Article
Language:English
Published: EDP Sciences 2013-11-01
Series:MATEC Web of Conferences
Online Access:http://dx.doi.org/10.1051/matecconf/20130704019
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spelling doaj-b2133927aae04e8f96a533ed65a46f042021-02-02T09:16:31ZengEDP SciencesMATEC Web of Conferences2261-236X2013-11-0170401910.1051/matecconf/20130704019Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutesHornez J.C.Bouchart F.Meurice E.Descamps M.Leriche A.Calcium phosphate ceramics like hydroxyapatite (HA) are widely used to repair and reconstruct damaged parts of the human skeleton. This material is currently available as injectable cements, granules or macroporous blocks. The most familiar materials are granule shaped ones because their conveniency to be implanted in human body. In this study, a new manufacturing procedure to fabricate dense, microporous and macroporous hydroxyapatite spherical granules based on a lost wax principle and allowing the fabrication of beads with a fully controlled porosity is presented. The HA granules porous structure is used to impregnation by gentamicine and other active substances. The drug and phage releasing kinetics are compared as a function of time and ceramic porosity. http://dx.doi.org/10.1051/matecconf/20130704019
collection DOAJ
language English
format Article
sources DOAJ
author Hornez J.C.
Bouchart F.
Meurice E.
Descamps M.
Leriche A.
spellingShingle Hornez J.C.
Bouchart F.
Meurice E.
Descamps M.
Leriche A.
Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
MATEC Web of Conferences
author_facet Hornez J.C.
Bouchart F.
Meurice E.
Descamps M.
Leriche A.
author_sort Hornez J.C.
title Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
title_short Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
title_full Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
title_fullStr Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
title_full_unstemmed Synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
title_sort synthesis and fabrication of porous calcium phosphate ceramics for antibacterial bone substitutes
publisher EDP Sciences
series MATEC Web of Conferences
issn 2261-236X
publishDate 2013-11-01
description Calcium phosphate ceramics like hydroxyapatite (HA) are widely used to repair and reconstruct damaged parts of the human skeleton. This material is currently available as injectable cements, granules or macroporous blocks. The most familiar materials are granule shaped ones because their conveniency to be implanted in human body. In this study, a new manufacturing procedure to fabricate dense, microporous and macroporous hydroxyapatite spherical granules based on a lost wax principle and allowing the fabrication of beads with a fully controlled porosity is presented. The HA granules porous structure is used to impregnation by gentamicine and other active substances. The drug and phage releasing kinetics are compared as a function of time and ceramic porosity.
url http://dx.doi.org/10.1051/matecconf/20130704019
work_keys_str_mv AT hornezjc synthesisandfabricationofporouscalciumphosphateceramicsforantibacterialbonesubstitutes
AT bouchartf synthesisandfabricationofporouscalciumphosphateceramicsforantibacterialbonesubstitutes
AT meuricee synthesisandfabricationofporouscalciumphosphateceramicsforantibacterialbonesubstitutes
AT descampsm synthesisandfabricationofporouscalciumphosphateceramicsforantibacterialbonesubstitutes
AT lerichea synthesisandfabricationofporouscalciumphosphateceramicsforantibacterialbonesubstitutes
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