Assessment of Relationship between Serum Level of Aminoterminal pro B-type Natriuretic Peptide and Prognosis in Patients with Respiratory Distress

• Main Authors: M Hoseini Kasnavieh, H Basirghafouri, H Reyhani, H Shaker, M Jafari Nodoushan, M Mashayekhian
• Format: Article
• Language: fas
• Published: Shahid Sadoughi University of Medical Sciences 2011-10-01
• Series: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
• Subjects: Natriuretic Peptide; Brain; Respiratory Distress Syndrome; Adult; Sensitivity and Specifity
• Online Access: http://85.185.157.11:6280/jssu/browse.php?a_id=1642&slc_lang=en&sid=1&ftxt=1

Introduction: The aim of this study was to assess the relationship between serum level of aminoterminal pro B-type natriuretic peptide and prognosis in patients with respiratory distress in emergency ward of Rasoul Akram Hospital(Tehran, Iran). Methods: In this cohort study which was conducted in the emergency ward of Rasoul Akram hospital, after considering inclusion ad exclusion criteria, 62 subjects with respiratory distress entered the study. Blood samples of these patients were used for assessment of NT-Pro-BNP levels; Finally, the survival of the patients was defined after 15 days and the levels of NT-Pro-BNP was compared between alive and dead patients. Data was analyzed by SPSS (Ver. 16). Results: Mean NT-Pro-BNP level was 8141.41(SD=10403.95). 10 patients (16.1%) died (8 females and 2 males) and 52 patients (83.9%) survived after 15 days. Mean NT-Pro-BNP level was 4674.34 (SD=6680.23) and 26170.20 (SD = 7073.80) among survived and died patients, respectively and the difference was statistically significant (p<0.001). Conclusion: Serum NT-Pro-BNP level can predict the prognosis of patients with respiratory distress due to such diseases as pulmonary edema, COPD exacerbation and CHF.