Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila

Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila

The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notu...

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Main Authors: Lydie Couturier, Khalil Mazouni, Francis Corson, François Schweisguth
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11477-2
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spelling doaj-b1e2fcacebd2420186e6c4bfdc70b5442021-05-11T11:33:24ZengNature Publishing GroupNature Communications2041-17232019-08-0110111310.1038/s41467-019-11477-2Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in DrosophilaLydie Couturier0Khalil Mazouni1Francis Corson2François Schweisguth3Department of Developmental and Stem Cell Biology, Institut PasteurDepartment of Developmental and Stem Cell Biology, Institut PasteurLaboratoire de Physique de l’Ecole Normale Supérieure, CNRS, Sorbonne Université, Université Paris DiderotDepartment of Developmental and Stem Cell Biology, Institut PasteurThe patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notum patterning.https://doi.org/10.1038/s41467-019-11477-2
collection DOAJ
language English
format Article
sources DOAJ
author Lydie Couturier
Khalil Mazouni
Francis Corson
François Schweisguth
spellingShingle Lydie Couturier
Khalil Mazouni
Francis Corson
François Schweisguth
Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
Nature Communications
author_facet Lydie Couturier
Khalil Mazouni
Francis Corson
François Schweisguth
author_sort Lydie Couturier
title Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_short Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_full Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_fullStr Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_full_unstemmed Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_sort regulation of notch output dynamics via specific e(spl)-hlh factors during bristle patterning in drosophila
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-08-01
description The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notum patterning.
url https://doi.org/10.1038/s41467-019-11477-2
work_keys_str_mv AT lydiecouturier regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila
AT khalilmazouni regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila
AT franciscorson regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila
AT francoisschweisguth regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila
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