A Novel Class of Cationic and Non-Peptidic Small Molecules as Hits for the Development of Antimicrobial Agents

A Novel Class of Cationic and Non-Peptidic Small Molecules as Hits for the Development of Antimicrobial Agents

Cationic and non-peptide small molecules containing a total of six positive charges arranged on one side and a long aliphatic tail on the other have been synthesized and tested against Gram-positive and Gram-negative bacteria. The positive charges have been contributed by two aminophenol residues. T...

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Bibliographic Details
Main Authors: Aranza Jiménez, Pablo García, Sofia de la Puente, Andrés Madrona, María José Camarasa, María-Jesús Pérez-Pérez, José-Carlos Quintela, Francisco García-del Portillo, Ana San-Félix
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
antimicrobial agents
antibiotic resistance
antimicrobial peptides
Online Access:http://www.mdpi.com/1420-3049/23/7/1513

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