Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres

Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres

Total alkaloids of <i>Alstonia scholaris</i> leaves (ASAs) are extracted from the lamp leaves, which have positive anti-inflammatory activity and remarkable effects in treating bronchitis. Due to its short half-life, we used a degradable mPEG-PLA to physically encapsulate the total alkal...

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Main Authors: Xiangyu Zheng, Hongli Li, Yi He, Mingwei Yuan, Meili Shen, Renyu Yang, Nianfeng Jiang, Minglong Yuan, Cui Yang
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Materials
Subjects:
total alkaloids from <i>Alstonia scholaris</i> leaves
mPEG-PLA
microspheres
drug release
biocompatibility
Online Access:https://www.mdpi.com/1996-1944/12/9/1457
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spelling doaj-b1c82e42c3ef4bf282ed853bb8d04bf82020-11-25T00:48:17ZengMDPI AGMaterials1996-19442019-05-01129145710.3390/ma12091457ma12091457Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA MicrospheresXiangyu Zheng0Hongli Li1Yi He2Mingwei Yuan3Meili Shen4Renyu Yang5Nianfeng Jiang6Minglong Yuan7Cui Yang8National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaNational and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaNational and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaNational and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaNational and Local Joint Engineering Laboratory for Synthesis Technology of High Performance Polymer, Jilin University, Changchun 130012, ChinaNational and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaNational and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaNational and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaNational and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, ChinaTotal alkaloids of <i>Alstonia scholaris</i> leaves (ASAs) are extracted from the lamp leaves, which have positive anti-inflammatory activity and remarkable effects in treating bronchitis. Due to its short half-life, we used a degradable mPEG-PLA to physically encapsulate the total alkali of the lamp stage, and prepared a sustained-release microsphere by double-emulsion method. The ASAs-loaded mPEG<sub>10000</sub>-PLA microspheres were screened for better performance by testing the morphology, average particle size, embedding rate and drug loading of different molecular weight mPEG-PLA microspheres, which can stably and continuously release for 15 days at 37 &#176;C. The results of cytotoxicity and blood compatibility indicated that the drug-loaded microspheres have beneficial biocompatibility. Animal experiments showed that the drug-loaded microspheres had a beneficial anti-inflammatory effect. These results all indicated that mPEG-PLA is a controlled release carrier material suitable for ASAs.https://www.mdpi.com/1996-1944/12/9/1457total alkaloids from <i>Alstonia scholaris</i> leavesmPEG-PLAmicrospheresdrug releasebiocompatibility
collection DOAJ
language English
format Article
sources DOAJ
author Xiangyu Zheng
Hongli Li
Yi He
Mingwei Yuan
Meili Shen
Renyu Yang
Nianfeng Jiang
Minglong Yuan
Cui Yang
spellingShingle Xiangyu Zheng
Hongli Li
Yi He
Mingwei Yuan
Meili Shen
Renyu Yang
Nianfeng Jiang
Minglong Yuan
Cui Yang
Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres
Materials
total alkaloids from <i>Alstonia scholaris</i> leaves
mPEG-PLA
microspheres
drug release
biocompatibility
author_facet Xiangyu Zheng
Hongli Li
Yi He
Mingwei Yuan
Meili Shen
Renyu Yang
Nianfeng Jiang
Minglong Yuan
Cui Yang
author_sort Xiangyu Zheng
title Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres
title_short Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres
title_full Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres
title_fullStr Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres
title_full_unstemmed Preparation and In Vitro Release of Total Alkaloids from <i>Alstonia Scholaris</i> Leaves Loaded mPEG-PLA Microspheres
title_sort preparation and in vitro release of total alkaloids from <i>alstonia scholaris</i> leaves loaded mpeg-pla microspheres
publisher MDPI AG
series Materials
issn 1996-1944
publishDate 2019-05-01
description Total alkaloids of <i>Alstonia scholaris</i> leaves (ASAs) are extracted from the lamp leaves, which have positive anti-inflammatory activity and remarkable effects in treating bronchitis. Due to its short half-life, we used a degradable mPEG-PLA to physically encapsulate the total alkali of the lamp stage, and prepared a sustained-release microsphere by double-emulsion method. The ASAs-loaded mPEG<sub>10000</sub>-PLA microspheres were screened for better performance by testing the morphology, average particle size, embedding rate and drug loading of different molecular weight mPEG-PLA microspheres, which can stably and continuously release for 15 days at 37 &#176;C. The results of cytotoxicity and blood compatibility indicated that the drug-loaded microspheres have beneficial biocompatibility. Animal experiments showed that the drug-loaded microspheres had a beneficial anti-inflammatory effect. These results all indicated that mPEG-PLA is a controlled release carrier material suitable for ASAs.
topic total alkaloids from <i>Alstonia scholaris</i> leaves
mPEG-PLA
microspheres
drug release
biocompatibility
url https://www.mdpi.com/1996-1944/12/9/1457
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