Sodium Currents in Striatal Neurons from Dystonic dtsz Hamsters: Altered Response to Lamotrigine

Dystonic mutant dtsz hamsters are a model for paroxysmal dystonia. Handling/stress provoke the dystonic attacks. This phenomenon subsedes with maturation, but can be reinvoked when these animals receive sodium channel blockers such as lamotrigine, suggesting a dysfunction of striatal sodium channels...

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Bibliographic Details
Main Authors: E. Siep, A. Richter, W. Löscher, E.-J. Speckmann, R. Köhling
Format: Article
Language:English
Published: Elsevier 2002-03-01
Series:Neurobiology of Disease
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Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904553

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