Pancreas Transplantation: Does Age Increase Morbidity?
Introduction. Pancreas transplantation (PTx) is the only definitive intervention for type 1 diabetes. Medical advancements in diabetes care have led to an aging PTx candidate pool. We report our experience with patients ≥50 years of age undergoing PTx. Methods. We reviewed 136 consecutive PTx patie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2011-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/596801 |
| Summary: | Introduction. Pancreas transplantation (PTx) is the only definitive intervention for type 1 diabetes. Medical advancements in diabetes care have led to an aging PTx candidate pool. We report our experience with patients ≥50 years of age undergoing PTx.
Methods. We reviewed 136 consecutive PTx patients at our institution from 1996–2010; 17 were ≥50 years of age. We evaluated demographics, surgical complications, acute rejection (AR) rates, nonsurgical infections, and survival outcomes.
Results. Demographic data was similar (𝑃>.05) between groups, excluding age. The two groups had comparable major and minor surgical complication rates (𝑃=.10 and 𝑃=.25, resp.). The older group had a lower 1-year and overall AR rate (𝑃=.04 and 𝑃=.03, resp.). The incidence of non-surgical infections and overall patient and graft survival was similar between groups (𝑃>.05). Conclusion. Older patients with type 1 diabetes are feasible candidates for PTx, as surgical morbidity, incidence of infections, and AR rates are low. |
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| ISSN: | 2090-0007 2090-0015 |