Metabolism in the tumor microenvironment: insights from single-cell analysis

The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single ce...

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Main Authors:	Zhengtao Xiao, Jason W. Locasale, Ziwei Dai
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-01-01
Series:	OncoImmunology
Subjects:	cancer metabolism immunometabolism tumor microenvironment single-cell rna sequencing
Online Access:	http://dx.doi.org/10.1080/2162402X.2020.1726556

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spelling	doaj-b1bd479fb62c432e8e18cafb5984f97a2021-09-24T14:41:23ZengTaylor & Francis GroupOncoImmunology2162-402X2020-01-019110.1080/2162402X.2020.17265561726556Metabolism in the tumor microenvironment: insights from single-cell analysisZhengtao Xiao0Jason W. Locasale1Ziwei Dai2Duke University School of MedicineMainline Station DriveDuke University School of MedicineThe metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy.http://dx.doi.org/10.1080/2162402X.2020.1726556cancer metabolismimmunometabolismtumor microenvironmentsingle-cell rna sequencing
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhengtao Xiao Jason W. Locasale Ziwei Dai
spellingShingle	Zhengtao Xiao Jason W. Locasale Ziwei Dai Metabolism in the tumor microenvironment: insights from single-cell analysis OncoImmunology cancer metabolism immunometabolism tumor microenvironment single-cell rna sequencing
author_facet	Zhengtao Xiao Jason W. Locasale Ziwei Dai
author_sort	Zhengtao Xiao
title	Metabolism in the tumor microenvironment: insights from single-cell analysis
title_short	Metabolism in the tumor microenvironment: insights from single-cell analysis
title_full	Metabolism in the tumor microenvironment: insights from single-cell analysis
title_fullStr	Metabolism in the tumor microenvironment: insights from single-cell analysis
title_full_unstemmed	Metabolism in the tumor microenvironment: insights from single-cell analysis
title_sort	metabolism in the tumor microenvironment: insights from single-cell analysis
publisher	Taylor & Francis Group
series	OncoImmunology
issn	2162-402X
publishDate	2020-01-01
description	The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy.
topic	cancer metabolism immunometabolism tumor microenvironment single-cell rna sequencing
url	http://dx.doi.org/10.1080/2162402X.2020.1726556
work_keys_str_mv	AT zhengtaoxiao metabolisminthetumormicroenvironmentinsightsfromsinglecellanalysis AT jasonwlocasale metabolisminthetumormicroenvironmentinsightsfromsinglecellanalysis AT ziweidai metabolisminthetumormicroenvironmentinsightsfromsinglecellanalysis
_version_	1717369781933309952

Metabolism in the tumor microenvironment: insights from single-cell analysis

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