Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.

Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.

Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated the impact of cholesterol accumulation, induced by U18666A, quinacrine or mutations in the cholesterol transporting Niemann-Pick disease type...

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Bibliographic Details
Main Authors: Hanna Appelqvist, Linnea Sandin, Karin Björnström, Paul Saftig, Brett Garner, Karin Ollinger, Katarina Kågedal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3500374?pdf=render

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