Expression Profiling and Functional Analysis of Candidate Col10a1 Regulators Identified by the TRAP Program

Expression Profiling and Functional Analysis of Candidate Col10a1 Regulators Identified by the TRAP Program

Hypertrophic chondrocytes and their specific marker, the type X collagen gene (Col10a1), are critical components of endochondral bone formation during skeletal development. We previously found that Runx2 is an indispensable mouse Col10a1 gene regulator and identified many other transcription factors...

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Bibliographic Details
Main Authors: Huiqin Bian, Ting Zhu, Yuting Liang, Ruoxuan Hei, Xiaojing Zhang, Xiaochen Li, Jinnan Chen, Yaojuan Lu, Junxia Gu, Longwei Qiao, Qiping Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
Col10a1 regulators
Tbx-5
Runx2
TRAP program
chondrocyte hypertrophy
skeletal disease
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.683939/full

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