Structural and Functional Characterization of a Unique AP Endonuclease From Deinococcus radiodurans

Structural and Functional Characterization of a Unique AP Endonuclease From Deinococcus radiodurans

Various endogenous and exogenous agents cause DNA damage, including apurinic/apyrimidinic (AP) sites. Due to their cytotoxic effects, AP sites are usually cleaved by AP endonuclease through the base excision repair (BER) pathway. Deinococcus radiodurans, an extraordinary radiation-resistant bacteriu...

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Bibliographic Details
Main Authors: Yuan He, Yiyi Wang, Chen Qin, Ying Xu, Kaiying Cheng, Hong Xu, Bing Tian, Ye Zhao, Liangyan Wang, Yuejin Hua
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
Deinococcus radiodurans
base excision repair
AP endonuclease
DrXth
genome stability
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01178/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01178/full

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