Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation

Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation

The Arp2/3 complex generates branched actin filament networks operating in cell edge protrusion and vesicle trafficking. Here we employ a conditional knockout mouse model permitting tissue- or cell-type specific deletion of the murine Actr3 gene (encoding Arp3). A functional Actr3 gene appeared esse...

Full description

Bibliographic Details
Main Authors: Vanessa Dimchev, Ines Lahmann, Stefan A. Koestler, Frieda Kage, Georgi Dimchev, Anika Steffen, Theresia E. B. Stradal, Franz Vauti, Hans-Henning Arnold, Klemens Rottner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
F-actin branching
lamellipodium
filopodium
migration
chemotaxis
F-actin turnover
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.634708/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.634708/full

Similar Items