Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms

Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms

The recombinant antibody fragments generated against the toxic components of scorpion venoms are considered a promising alternative for obtaining new antivenoms for therapy. Using directed evolution and site-directed mutagenesis, it was possible to generate a human single-chain antibody fragment wit...

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Bibliographic Details
Main Authors: Lidia Riaño-Umbarila, Ilse V. Gómez-Ramírez, Luis M. Ledezma-Candanoza, Timoteo Olamendi-Portugal, Everardo Remi Rodríguez-Rodríguez, Guillermo Fernández-Taboada, Lourival D. Possani, Baltazar Becerril
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Toxins
Subjects:
cross-neutralization
directed evolution
phage display
polyvalent antivenom
scFv
scorpion
Online Access:http://www.mdpi.com/2072-6651/11/1/32

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