Evaluation of Sugar Residues in Zona Pellucida During Ovarian Cycle

• Main Authors: Mohammad Barbarestani, Seyyed Mohammad Hosseinipanah, Ali Reza Fazel, Mehran Rezei Habibi, Mostafa Hoseini, Mohammad Akbari, Farid Abolhasani, Mir Abbas Mir Abdolvahabi
• Format: Article
• Language: fas
• Published: Hamadan University of Medical Sciences 2003-12-01
• Series: پزشکی بالینی ابن سینا
• Subjects: glycoconjugate; lectin; ovary
• Online Access: http://sjh.umsha.ac.ir/article-1-660-en.html
• ISSN: 2588-722X; 2588-7238

Glycoconjugates, particulary their sugar side chains, play important roles in development. This investigation was undertaken to examine the chemical nature of components in the zona pellucida possibly related to follicular development.           In this study, lectins conjugated to horseradish peroxidase were used as specific histochemical probes to characterize the structure of zona pellucida glycoconjugates and changes in their composition during ovarian cycle.           Three of five lectins for N-acetylation of galactose and glucose amine intensely stained the zona pellucida.           These observations suggest that the N-acetylgalactosamine (GalNAc) and N-Acetylglucosamine (GlcNAc)-containing glycoconjugates in zona pellucida may be of functional important in follicular development. We can  use this data for causing female infertility and to make special    contraceptive.