Blood-brain barrier breakdown and repair following gliotoxic drug injection in the brainstem of streptozotocin-diabetic rats

Ethidium bromide (EB) causes local astrocytic disappearance, with glia limitans disruption and blood-brain barrier (BBB) breakdown. The aim of this study was to evaluate the BBB integrity after the injection of 0.1% EB or 0.9% saline solution into the cisterna pontis of Wistar rats submitted or not...

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Bibliographic Details
Main Authors: Eduardo Fernandes Bondan, Maria de Fátima Monteiro Martins
Format: Article
Language:English
Published: Academia Brasileira de Neurologia (ABNEURO) 2012-03-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000300013&lng=en&tlng=en