Is Factor V Leiden a Risk Factor for Fetal Loss?

• Main Authors: Petr Dulíček, Ladislav Chrobák, Ivo Kalousek, Lenka Pešavová, Miroslav Pecka, Pravoslav Stránský
• Format: Article
• Language: English
• Published: Karolinum Press 1999-01-01
• Series: Acta Medica
• Subjects: Placental infarction; Hypercoagulable state; APC resistance; F V Leiden; Venous thromboembolism; Fetal loss
• Online Access: https://actamedica.lfhk.cuni.cz/42/3/0093/

A successful pregnancy is dependent on the development of adequate placental circulation. The abnormalities of placental vasculature may result in a number of gestational pathologies, including fetal loss. The aim of our study was to determine whether women with f V Leiden are at an increased risk of pregnancy loss. For this purpose we assessed three groups of women. In a prospective group we examined 30 females with spontaneous abortions for f V Leiden. In a retrospective group we assessed the frequency of abortions in 80 women (l72 pregnancies) with f V Leiden (72 heterozygous, 8 homozygous) from 57 unrelated families. In a control group we evaluated the frequency of abortions in 45 women without f V Leiden. Factor V Leiden was found in 3% of women in the 1st group. Fetal loss occurred in 10% of women in the 2nd group and in 9% in the 3rd group. Factor V Leiden was not found to be a risk factor for fetal loss in our study group.