Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia.

Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia.

The family of zinc finger-containing GATA transcription factors plays critical roles in cell lineage specification during early embryonic development and organ formation. GATA4 and GATA6 were found to be frequently lost in ovarian cancer, and the loss is proposed to account for dedifferentiation of...

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Bibliographic Details
Main Authors: Kathy Qi Cai, Corrado Caslini, Callinice D Capo-chichi, Carolyn Slater, Elizabeth R Smith, Hong Wu, Andres J Klein-Szanto, Andrew K Godwin, Xiang-Xi Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2715102?pdf=render

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