Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM

Advances in Knowledge of Candidate Genes Acting at the Beta-Cell Level in the Pathogenesis of T1DM

T1DM (type 1 diabetes mellitus), which results from the irreversible elimination of beta-cells mediated by autoreactive T cells, is defined as an autoimmune disease. It is widely accepted that T1DM is caused by a combination of genetic and environmental factors, but the precise underlying molecular...

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Bibliographic Details
Main Authors: Haipeng Pang, Shuoming Luo, Gan Huang, Ying Xia, Zhiguo Xie, Zhiguang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Endocrinology
Subjects:
T1DM
GWAS
pancreatic beta-cell
candidate gene
apoptosis
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00119/full

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