A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.

A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.

Fcgamma receptor (FcgammaR)-mediated phagocytosis of IgG-coated particles is regulated by 3'-phosphoinositides (3'PIs) and several classes of small GTPases, including ARF6 from the ADP Ribosylation Factor subfamily. The insensitivity of phagocytosis to brefeldin A (BFA), an inhibitor of ce...

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Bibliographic Details
Main Authors: Peter Beemiller, Adam D Hoppe, Joel A Swanson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1457017?pdf=render

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