The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment

The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug resistance. However, recent evidence showed that tumor microenvironment (TME) is essential for regulating immune esca...

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Bibliographic Details
Main Authors: Yanghong Ni, Xiaoting Zhou, Jia Yang, Houhui Shi, Hongyi Li, Xia Zhao, Xuelei Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor microenvironment
antineoplastic drug resistance
cell-cell interplays
CAFs
TAMs
MSCs
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.637675/full

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