Highly sensitive detection of ALK resistance mutations in plasma using droplet digital PCR

Highly sensitive detection of ALK resistance mutations in plasma using droplet digital PCR

Abstract Background On-target resistance mechanisms found in one-third of patients receiving anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are secondary ALK mutations in ALK-rearranged non-small cell lung cancer (NSCLC). There are large variations in the resistant mutations, unl...

Full description

Bibliographic Details
Main Authors: Ryohei Yoshida, Takaaki Sasaki, Yasuhiro Umekage, Sachie Tanno, Yusuke Ono, Munehiko Ogata, Shinichi Chiba, Yusuke Mizukami, Yoshinobu Ohsaki
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Cancer
Subjects:
Resistance
ALK inhibitors
Liquid biopsy
Cell-free DNA (cfDNA)
Droplet digital PCR (ddPCR)
Online Access:http://link.springer.com/article/10.1186/s12885-018-5031-0

Internet

http://link.springer.com/article/10.1186/s12885-018-5031-0

Similar Items