POEM: Identifying joint additive effects on regulatory circuits

POEM: Identifying joint additive effects on regulatory circuits

Motivation: Expression Quantitative Trait Locus (eQTL) mapping tackles the problem of identifying variation in DNA sequence that have an effect on the transcriptional regulatory network. Major computational efforts are aimed at characterizing the joint effects of several eQTLs acting in concert to g...

Full description

Bibliographic Details
Main Authors:	Maya eBotzman, Aharon eNachshon, Avital eBrodt, Irit eGat-Viks
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-04-01
Series:	Frontiers in Genetics
Subjects:	eQTL Additive effects Gene modules pairwise effects immune signaling netwrok
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00048/full

Similar Items

The impact of cell type and context-dependent regulatory variants on human immune traits
by: Zepeng Mu, et al.
Published: (2021-04-01)

Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer’s disease created by integrative analysis of multi-omics data
by: Daichi Shigemizu, et al.
Published: (2020-11-01)

Genetics of trans-regulatory variation in gene expression
by: Frank Wolfgang Albert, et al.
Published: (2018-07-01)

eQTL discovery and their association with severe equine asthma in European Warmblood horses
by: Victor C. Mason, et al.
Published: (2018-08-01)

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts
by: Benjamin H. Mullin, et al.
Published: (2020-03-01)

Dissecting dynamic genetic variation that controls temporal gene response in yeast.
by: Avital Brodt, et al.
Published: (2014-12-01)

Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes
by: Yehudit Hasin-Brumshtein, et al.
Published: (2016-09-01)

Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross
by: Kaushik Renganaath, et al.
Published: (2020-11-01)

Alternative polyadenylation mediates genetic regulation of gene expression
by: Briana E Mittleman, et al.
Published: (2020-06-01)

Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
by: Dena G. Hernandez, et al.
Published: (2012-07-01)

Overlap between eQTL and QTL associated with production traits and fertility in dairy cattle
by: I. van den Berg, et al.
Published: (2019-04-01)

eQTpLot: a user-friendly R package for the visualization of colocalization between eQTL and GWAS signals
by: Theodore G. Drivas, et al.
Published: (2021-07-01)

Compensatory trans‐regulatory alleles minimizing variation in TDH3 expression are common within Saccharomyces cerevisiae
by: Brian P. H. Metzger, et al.
Published: (2019-10-01)

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative Analyses
by: Ancha Baranova, et al.
Published: (2021-09-01)

Identification of putative regulatory regions and transcription factors associated with intramuscular fat content traits
by: Aline S. M. Cesar, et al.
Published: (2018-06-01)

Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial
by: Emma E. Davenport, et al.
Published: (2018-10-01)

Regulatory Architecture of Gene Expression Variation in the Threespine Stickleback Gasterosteus aculeatus
by: Victoria L. Pritchard, et al.
Published: (2017-01-01)

eQTLMAPT: Fast and Accurate eQTL Mediation Analysis With Efficient Permutation Testing Approaches
by: Tao Wang, et al.
Published: (2020-01-01)

Prospects for Advancing Defense to Cereal Rusts through Genetical Genomics
by: Elsa eBallini, et al.
Published: (2013-05-01)

Topology, robustness, and structural controllability of the Brazilian Federal Police criminal intelligence network
by: Bruno Requião da Cunha, et al.
Published: (2018-08-01)

Genetic Analysis of Methyl Anthranilate, Mesifurane, Linalool, and Other Flavor Compounds in Cultivated Strawberry (Fragaria × ananassa)
by: Christopher R. Barbey, et al.
Published: (2021-05-01)

Expression variation in connected recombinant populations of <it>Arabidopsis thaliana </it>highlights distinct transcriptome architectures
by: Cubillos Francisco A, et al.
Published: (2012-03-01)

Integrate GWAS, eQTL, and mQTL Data to Identify Alzheimer’s Disease-Related Genes
by: Tianyi Zhao, et al.
Published: (2019-10-01)

Mapping QTL for white striping in relation to breast muscle yield and meat quality traits in broiler chickens
by: Eva Pampouille, et al.
Published: (2018-03-01)

Genetical genomics of growth in a chicken model
by: Martin Johnsson, et al.
Published: (2018-01-01)

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken
by: Martin Johnsson, et al.
Published: (2016-02-01)

Characterizing human genomic coevolution in locus-gene regulatory interactions
by: Daniel Savel, et al.
Published: (2019-03-01)

Significant common environmental effects on leukocyte subpopulations.
by: Maya Botzman, et al.
Published: (2018-01-01)

Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants
by: Devanshi Patel, et al.
Published: (2021-03-01)

Sex-specific modulation of gene expression networks in murine hypothalamus
by: Khyobeni eMozhui, et al.
Published: (2012-05-01)

Genetical Genomics of Tonic Immobility in the Chicken
by: Jesper Fogelholm, et al.
Published: (2019-05-01)

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
by: Siriluck Ponsuksili, et al.
Published: (2019-04-01)

Gene expression variability in human and chimpanzee populations share common determinants
by: Benjamin Jung Fair, et al.
Published: (2020-10-01)

eQTL epistasis – challenges and computational approaches
by: Yang eHuang, et al.
Published: (2013-05-01)

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction
by: Joel Lavinsky, et al.
Published: (2016-10-01)

Genetic Mechanism Revealed of Age-Related Macular Degeneration Based on Fusion of Statistics and Machine Learning Method
by: Yongyi Du, et al.
Published: (2021-08-01)

Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants
by: Liis Kolberg, et al.
Published: (2020-09-01)

Review: transcriptome and trans-omics analysis of systemic lupus erythematosus
by: Keishi Fujio, et al.
Published: (2020-06-01)

Dyslexia risk variant rs600753 is linked with dyslexia-specific differential allelic expression of DYX1C1
by: Bent Müller, et al.
Published: (2018-02-01)

Deconvolution of bulk blood eQTL effects into immune cell subpopulations
by: Raúl Aguirre-Gamboa, et al.
Published: (2020-06-01)