Interleukin-1 Modulation of Human Placental Trophoblast Proliferation
During early pregnancy, interleukin-1 (IL-1) is mainly produced and secreted by maternal decidua. Yet, its biological function on placental cells is not well defined. In this study, we employed JAR choriocarcinoma cell line as a model of human placental trophoblast to study the effect of IL-1. Treat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/79359 |
| Summary: | During early pregnancy, interleukin-1 (IL-1) is mainly produced
and secreted by maternal decidua. Yet, its biological function on
placental cells is not well defined. In this study, we employed
JAR choriocarcinoma cell line as a model of human placental
trophoblast to study the effect of IL-1. Treatment with
recombinant human IL-1β resulted in significant inhibition
of JAR proliferation (P<.05) paralleled with increased
cytotoxicity. The inhibitory effect was blocked by both IL-1
receptor antagonist (IL-1Ra) and antihuman IL-1β monoclonal antibody. Analyzing the mode of action, IL-1β was found to induce cell cycle arrest in the G0/G1 phase and triggered
apoptotic cell death. These findings demonstrated that IL-1
regulates human trophoblast growth by induction of cell cycle
delay and cell death. |
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| ISSN: | 0962-9351 1466-1861 |