A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors
False positive results significantly slow down the drug discovery process. Here, the authors developed a gel serving as a screening platform in which enzymes can be stored, stabilized, and protected from most of the compounds that typically cause these misleading results.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-02956-z |
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doaj-b15875df484545e4be2b90b2fc1c4eda |
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Article |
| spelling |
doaj-b15875df484545e4be2b90b2fc1c4eda2021-05-11T10:29:01ZengNature Publishing GroupNature Communications2041-17232018-02-01911910.1038/s41467-018-02956-zA printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitorsRabia Mateen0M. Monsur Ali1Todd Hoare2School of Biomedical Engineering, McMaster UniversityBiointerfaces Institute, McMaster UniversitySchool of Biomedical Engineering, McMaster UniversityFalse positive results significantly slow down the drug discovery process. Here, the authors developed a gel serving as a screening platform in which enzymes can be stored, stabilized, and protected from most of the compounds that typically cause these misleading results.https://doi.org/10.1038/s41467-018-02956-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Rabia Mateen M. Monsur Ali Todd Hoare |
| spellingShingle |
Rabia Mateen M. Monsur Ali Todd Hoare A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors Nature Communications |
| author_facet |
Rabia Mateen M. Monsur Ali Todd Hoare |
| author_sort |
Rabia Mateen |
| title |
A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors |
| title_short |
A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors |
| title_full |
A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors |
| title_fullStr |
A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors |
| title_full_unstemmed |
A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors |
| title_sort |
printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-02-01 |
| description |
False positive results significantly slow down the drug discovery process. Here, the authors developed a gel serving as a screening platform in which enzymes can be stored, stabilized, and protected from most of the compounds that typically cause these misleading results. |
| url |
https://doi.org/10.1038/s41467-018-02956-z |
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