Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose.

Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose.

Previous studies have shown that high glucose increases reactive oxygen species (ROS) in endothelial cells that contributes to vascular dysfunction and atherosclerosis. Accumulation of ROS is due to dysregulated redox balance between ROS-producing systems and antioxidant systems. Previous research f...

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Bibliographic Details
Main Authors: Zhaoyun Zhang, Zhihong Yang, Bo Zhu, Ji Hu, Chong Wee Liew, Yingyi Zhang, Jane A Leopold, Diane E Handy, Joseph Loscalzo, Robert C Stanton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3501497?pdf=render

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