Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein

Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein

C-terminal Src kinase (CSK) is a major negative regulator of Src family tyrosine kinases (SFKs) that play critical roles in immunoreceptor signaling. CSK is brought in contiguity to the plasma membrane-bound SFKs via binding to transmembrane adaptor PAG, also known as CSK-binding protein. The recent...

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Bibliographic Details
Main Authors: Lucie Potuckova, Lubica Draberova, Ivana Halova, Tomas Paulenda, Petr Draber
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
mast cell
degranulation
cytokines
C-terminal Src kinase
phosphoprotein associated with glycosphingolipid-enriched microdomains
LYN
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01771/full

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