Autophagy in Premature Senescent Cells Is Activated via AMPK Pathway

Autophagy in Premature Senescent Cells Is Activated via AMPK Pathway

Autophagy is a highly regulated intracellular process involved in the turnover of most cellular constituents and in the maintenance of cellular homeostasis. In this study, we show that the activity of autophagy increases in H2O2 or RasV12-induced senescent fibroblasts. Inhibiting autophagy promotes...

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Bibliographic Details
Main Authors: Liujing Guo, Zebin Mao, Bushan Xie
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
senescent cells
apoptosis
FoxO3A
AMPK
fibroblasts
Online Access:http://www.mdpi.com/1422-0067/13/3/3563/

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