FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer

FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer

Abstract Background Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remains elusive. Methods Apolipoprotein (ApoE) knock-out mice was used to an...

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Bibliographic Details
Main Authors: Huiling Lai, Xuejiao Zhao, Yu Qin, Yi Ding, Ruqi Chen, Guannan Li, Marilyne Labrie, Zhiyong Ding, Jianfeng Zhou, Junbo Hu, Ding Ma, Yong Fang, Qinglei Gao
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Apolipoprotein E
Extracellular matrix
Ovarian cancer
Tumor progression
Adhesion
Online Access:http://link.springer.com/article/10.1186/s13046-018-0696-4

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