Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells

Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells

Abstract Background Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment was often associated with poor prognosis and reduced cytotoxic T cell in...

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Bibliographic Details
Main Authors: Shijia Wang, Guan Wang, Liying Zhang, Fengying Li, Keli Liu, Ying Wang, Yufang Shi, Kai Cao
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cell & Bioscience
Subjects:
Mesenchymal stem/stromal cells
Programmed death-ligand 1
Interleukin-17
Nitric oxide
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13578-020-00431-1

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