The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

The Histone Methyltransferase DOT1L Is Essential for Humoral Immune Responses

Summary: Histone modifiers are essential for the ability of immune cells to reprogram their gene expression during differentiation. The recruitment of the histone methyltransferase DOT1L (disruptor of telomeric silencing 1-like) induces oncogenic gene expression in a subset of B cell leukemias. Desp...

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Bibliographic Details
Main Authors: Liam Kealy, Andrea Di Pietro, Lauren Hailes, Sebastian Scheer, Lennard Dalit, Joanna R. Groom, Colby Zaph, Kim L. Good-Jacobson
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
B cells
antibody
epigenetics
DOT1L
humoral responses
H3K79
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314935

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