Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA

Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA

The importance of a balanced T<sub>H</sub>1/T<sub>H</sub>2 humoral immune response against the HIV-1 envelope protein (Env) for antibody-mediated HIV-1 control is increasingly recognized. However, there is no defined vaccination strategy to raise it. Since immune checkpoints...

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Bibliographic Details
Main Authors: Pierre Tannig, Antonia Sophia Peter, Dennis Lapuente, Stephan Klessing, Dominik Damm, Matthias Tenbusch, Klaus Überla, Vladimir Temchura
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Vaccines
Subjects:
hiv-1
checkpoint inhibitors
checkpoint blockade
intramuscular electroporation
soluble immune checkpoints
immunomodulation
Online Access:https://www.mdpi.com/2076-393X/8/1/27

Internet

https://www.mdpi.com/2076-393X/8/1/27

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