TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
The protein cGAS responds to the presence of cytosolic DNA by producing the second messenger cGAMP, which triggers antiviral interferon responses. Here, Seo et al. show that ubiquitination by the E3 ligase TRIM56 enhances cGAS activity and is important for the immune response against DNA viruses.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-02936-3 |
| Summary: | The protein cGAS responds to the presence of cytosolic DNA by producing the second messenger cGAMP, which triggers antiviral interferon responses. Here, Seo et al. show that ubiquitination by the E3 ligase TRIM56 enhances cGAS activity and is important for the immune response against DNA viruses. |
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| ISSN: | 2041-1723 |