MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors

Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.

Bibliographic Details
Main Authors: Xinyue Chen, Daniel B. Burkhardt, Amaleah A. Hartman, Xiao Hu, Anna E. Eastman, Chao Sun, Xujun Wang, Mei Zhong, Smita Krishnaswamy, Shangqin Guo
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13666-5
id doaj-b111a4d94fc0407fb663f8993929840c
record_format Article
spelling doaj-b111a4d94fc0407fb663f8993929840c2021-05-11T12:21:27ZengNature Publishing GroupNature Communications2041-17232019-12-0110111510.1038/s41467-019-13666-5MLL-AF9 initiates transformation from fast-proliferating myeloid progenitorsXinyue Chen0Daniel B. Burkhardt1Amaleah A. Hartman2Xiao Hu3Anna E. Eastman4Chao Sun5Xujun Wang6Mei Zhong7Smita Krishnaswamy8Shangqin Guo9Department of Cell Biology, Yale UniversityDepartment of Genetics, Yale UniversityDepartment of Cell Biology, Yale UniversityDepartment of Cell Biology, Yale UniversityDepartment of Cell Biology, Yale UniversityDepartment of Cell Biology, Yale UniversitySJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong UniversityDepartment of Cell Biology, Yale UniversityDepartment of Genetics, Yale UniversityDepartment of Cell Biology, Yale UniversityNot all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.https://doi.org/10.1038/s41467-019-13666-5
collection DOAJ
language English
format Article
sources DOAJ
author Xinyue Chen
Daniel B. Burkhardt
Amaleah A. Hartman
Xiao Hu
Anna E. Eastman
Chao Sun
Xujun Wang
Mei Zhong
Smita Krishnaswamy
Shangqin Guo
spellingShingle Xinyue Chen
Daniel B. Burkhardt
Amaleah A. Hartman
Xiao Hu
Anna E. Eastman
Chao Sun
Xujun Wang
Mei Zhong
Smita Krishnaswamy
Shangqin Guo
MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
Nature Communications
author_facet Xinyue Chen
Daniel B. Burkhardt
Amaleah A. Hartman
Xiao Hu
Anna E. Eastman
Chao Sun
Xujun Wang
Mei Zhong
Smita Krishnaswamy
Shangqin Guo
author_sort Xinyue Chen
title MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_short MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_full MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_fullStr MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_full_unstemmed MLL-AF9 initiates transformation from fast-proliferating myeloid progenitors
title_sort mll-af9 initiates transformation from fast-proliferating myeloid progenitors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-12-01
description Not all mutated cells become malignant, suggesting additional requirements for transformation. Here, the authors track blood progenitors from normal to malignancy driven by MLL-AF9, revealing a subset of myeloid progenitors predisposed to transformation dependent on their normal cycling state.
url https://doi.org/10.1038/s41467-019-13666-5
work_keys_str_mv AT xinyuechen mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT danielbburkhardt mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT amaleahahartman mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT xiaohu mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT annaeeastman mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT chaosun mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT xujunwang mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT meizhong mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT smitakrishnaswamy mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
AT shangqinguo mllaf9initiatestransformationfromfastproliferatingmyeloidprogenitors
_version_ 1721444959165349888

Similar Items