IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters

IRF4 and STAT3 activities are associated with the imbalanced differentiation of T-cells in responses to inhalable particulate matters

Abstract Background Particulate Matter (PM) is known to cause inflammatory responses in human. Although prior studies verified the immunogenicity of PM in cell lines and animal models, the effectors of PM exposure in the respiratory system and the regulators of the immunogenicity of PM is not fully...

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Main Authors: Jinzhun Wu, Dandan Ge, Taoling Zhong, Zuojia Chen, Ying Zhou, Lingyun Hou, Xiaoliang Lin, Jiaxu Hong, Kuai Liu, Hui Qi, Chaoying Wang, Yulin Zhou, Cheng Li, Chuan Wu, Shuiping Wu, Zuguo Liu, Qiyuan Li
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Respiratory Research
Subjects:
Particulate matters
Gene expression profiling
Allergic respiratory disease
Imbalanced T-cell differentiation
Transcription factor
Online Access:http://link.springer.com/article/10.1186/s12931-020-01368-2

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