Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines

Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines

Prostate cancer is one of the cause of mortality and morbidity in men. High nutritional quality mushrooms have been consumed as food for a long time and Thanks to their bioactive components, they can be used in many fields such as pharmaceuticals, cosmetic products, dietary supplements and functiona...

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Bibliographic Details
Main Authors: Hatice Bekci, Mustafa Cam, Ahmet Cumaoglu
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Proceedings
Subjects:
mushroom
anticancer
prostate cell line
Online Access:https://www.mdpi.com/2504-3900/40/1/40
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spelling doaj-b0ee7befaf6945f38edd6427b10400b12020-11-25T01:54:14ZengMDPI AGProceedings2504-39002019-12-014014010.3390/proceedings2019040040proceedings2019040040Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell LinesHatice Bekci0Mustafa Cam1Ahmet Cumaoglu2Vocational Sciences, Kayseri University, 38039 Kayseri, TurkeyDepartment of Food Engineering, Faculty of Engineering, Erciyes University, 38039 Kayseri, TurkeyFaculty of Pharmacy, Erciyes University, 38039 Kayseri, TurkeyProstate cancer is one of the cause of mortality and morbidity in men. High nutritional quality mushrooms have been consumed as food for a long time and Thanks to their bioactive components, they can be used in many fields such as pharmaceuticals, cosmetic products, dietary supplements and functional food production. The purpose of the research was to evaluate these derivatives against in vitro to obtain novel specific and effective anticancer agents against prostate cancer. In the study, <i>Amanita caesarea, Sparassis crispa, Lepista nuda, Auricularia auricula, Tricholoma terreum </i>and<i> Lentinus tigrinus</i> fungi were used. Anticancer activities of the compounds were evaluated in vitro by using MTT method against PC-3 and DU-143 (androgen-independent human prostate cancer cell lines) prostate cancer cell lines. Cisplatin was used as the positive sensitivity reference standard. The most effective among these fungus species biological activity against PC3 cancer cell line (IC<sub>50</sub> = 327.34 µM), against DU-145 (IC<sub>50</sub> = 459.19 µM).https://www.mdpi.com/2504-3900/40/1/40mushroomanticancerprostate cell line
collection DOAJ
language English
format Article
sources DOAJ
author Hatice Bekci
Mustafa Cam
Ahmet Cumaoglu
spellingShingle Hatice Bekci
Mustafa Cam
Ahmet Cumaoglu
Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines
Proceedings
mushroom
anticancer
prostate cell line
author_facet Hatice Bekci
Mustafa Cam
Ahmet Cumaoglu
author_sort Hatice Bekci
title Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines
title_short Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines
title_full Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines
title_fullStr Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines
title_full_unstemmed Some Wild Edible Mushroom Anticancer Activity Against Prostate Cell Lines
title_sort some wild edible mushroom anticancer activity against prostate cell lines
publisher MDPI AG
series Proceedings
issn 2504-3900
publishDate 2019-12-01
description Prostate cancer is one of the cause of mortality and morbidity in men. High nutritional quality mushrooms have been consumed as food for a long time and Thanks to their bioactive components, they can be used in many fields such as pharmaceuticals, cosmetic products, dietary supplements and functional food production. The purpose of the research was to evaluate these derivatives against in vitro to obtain novel specific and effective anticancer agents against prostate cancer. In the study, <i>Amanita caesarea, Sparassis crispa, Lepista nuda, Auricularia auricula, Tricholoma terreum </i>and<i> Lentinus tigrinus</i> fungi were used. Anticancer activities of the compounds were evaluated in vitro by using MTT method against PC-3 and DU-143 (androgen-independent human prostate cancer cell lines) prostate cancer cell lines. Cisplatin was used as the positive sensitivity reference standard. The most effective among these fungus species biological activity against PC3 cancer cell line (IC<sub>50</sub> = 327.34 µM), against DU-145 (IC<sub>50</sub> = 459.19 µM).
topic mushroom
anticancer
prostate cell line
url https://www.mdpi.com/2504-3900/40/1/40
work_keys_str_mv AT haticebekci somewildediblemushroomanticanceractivityagainstprostatecelllines
AT mustafacam somewildediblemushroomanticanceractivityagainstprostatecelllines
AT ahmetcumaoglu somewildediblemushroomanticanceractivityagainstprostatecelllines
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