| Summary: | Prostate cancer is one of the cause of mortality and morbidity in men. High nutritional quality mushrooms have been consumed as food for a long time and Thanks to their bioactive components, they can be used in many fields such as pharmaceuticals, cosmetic products, dietary supplements and functional food production. The purpose of the research was to evaluate these derivatives against in vitro to obtain novel specific and effective anticancer agents against prostate cancer. In the study, <i>Amanita caesarea, Sparassis crispa, Lepista nuda, Auricularia auricula, Tricholoma terreum </i>and<i> Lentinus tigrinus</i> fungi were used. Anticancer activities of the compounds were evaluated in vitro by using MTT method against PC-3 and DU-143 (androgen-independent human prostate cancer cell lines) prostate cancer cell lines. Cisplatin was used as the positive sensitivity reference standard. The most effective among these fungus species biological activity against PC3 cancer cell line (IC<sub>50</sub> = 327.34 µM), against DU-145 (IC<sub>50</sub> = 459.19 µM).
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