Metabolism of Estrogens: Turnover Differs between Platinum-Sensitive and -Resistant High-Grade Serous Ovarian Cancer Cells

Metabolism of Estrogens: Turnover Differs between Platinum-Sensitive and -Resistant High-Grade Serous Ovarian Cancer Cells

High-grade serous ovarian cancer (HGSOC) is currently treated with cytoreductive surgery and platinum-based chemotherapy. The majority of patients show a primary response; however, many rapidly develop drug resistance. Antiestrogens have been studied as low toxic treatment options for HGSOC, with hi...

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Bibliographic Details
Main Authors: Stefan Poschner, Judith Wackerlig, Dan Cacsire Castillo-Tong, Andrea Wolf, Isabel von der Decken, Tea Lanišnik Rižner, Renata Pavlič, Anastasia Meshcheryakova, Diana Mechtcheriakova, Monika Fritzer-Szekeres, Theresia Thalhammer, Walter Jäger
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
high-grade serous ovarian cancer
steroid hormones
metabolomics
lc-hrms
carboplatin resistance
interleukin-6
Online Access:https://www.mdpi.com/2072-6694/12/2/279

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