Anti-TNF-α agents Modulate SARS-CoV-2 Receptors and Increase the Risk of Infection Through Notch-1 Signaling

Anti-TNF-α agents Modulate SARS-CoV-2 Receptors and Increase the Risk of Infection Through Notch-1 Signaling

Although millions of patients with underlining conditions are treated primarily with anti-TNF-α agents, little is known about the safety of this standard therapy during the coronavirus disease-2019 (COVID-19) pandemic. In this study, we investigated the effect of anti-TNF-α monoclonal antibodies on...

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Bibliographic Details
Main Authors: Esra’a Keewan, Shazia Beg, Saleh A. Naser
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
COVID19
SARS-CoV-2
TACE
ACE2
Notch
anti-TNF-α
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641295/full

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