Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload
Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expres...
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doaj-b0d2f7679b0446c39210399d4b06b22c2020-11-25T04:00:11ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110577878510.4103/1673-5374.156981Effective components of Chinese herbs reduce central nervous system function decline induced by iron overloadXian-hui DongJiang-tao BaiWei-na KongXiao-ping HePeng YanTie-mei ShaoWen-guo YuXi-qing ChaiYan-hua WuCong LIuAbnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer′s disease patients. An APP swe/PS1ΔE9 double transgenic mouse model of Alzheimer′s disease was used. The intragastric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer′s disease. These compounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer′s disease.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=778;epage=785;aulast=Dongactive zone stabilityDrosophilaneuromuscular junctiondephosphorylationLiprin-αSyd-1PP2AGSK-3ßliving scaffoldsneural tissue engineeringcell transplantbiomaterialsregenerationneurotraumaneurodegenerationaxon pathfindingcell migrationinjuryplasticityneurodegenerative diseasebraintherapyneuronmicroglianeural progenitortissue engineeringneuroregenerationrepaircentral nervous systembiomaterialregenerative medicinenanotechnologyspinal cord injuryaxonal regenerationexosomeextracellular vesiclemicroRNAmicrovesiclenerve gapneurite outgrowthperipheral nerve injurySchwann cellstem cellhemodynamic phasescerebral subarachnoid hemorrhagemetabolic crisesnerve regenerationhypoxic-ischemic brain damageginsenoside Rg1neural stem cellscell transplantationcell differentiationcognitionnerve reconstructionneural regenerationnerve regenerationbrain injuryneuroimagingfunctional magnetic resonance imagingregional homogeneityapoplexysubacuteischemiaparticipantshealthyvolunteersbrain activityNSFC grantsneural regenerationnerve regenerationbrain injuryneuroprotectioncerebral ischemia/reperfusion injurylateral intracerebroventricular injectionApelin-13nerve apoptosisBcl-2caspase-3NSFC grantsneural regenerationnerve regenerationfractalkineCX3 chemokine receptor 1neuronal maturationdendritesdoublecortinsynaptic maturationnewborn neuronsneural regenerationnerve regenerationneurodegenerative diseasesAlzheimer′s diseasetransgenic animal modelsmiceepimedium herbmilkvetch rootkudzuvine rootdivalent metal transporter 1ferroportin 1neural regeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xian-hui Dong Jiang-tao Bai Wei-na Kong Xiao-ping He Peng Yan Tie-mei Shao Wen-guo Yu Xi-qing Chai Yan-hua Wu Cong LIu |
spellingShingle |
Xian-hui Dong Jiang-tao Bai Wei-na Kong Xiao-ping He Peng Yan Tie-mei Shao Wen-guo Yu Xi-qing Chai Yan-hua Wu Cong LIu Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload Neural Regeneration Research active zone stability Drosophila neuromuscular junction dephosphorylation Liprin-α Syd-1 PP2A GSK-3ß living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration injury plasticity neurodegenerative disease brain therapy neuron microglia neural progenitor tissue engineering neuroregeneration repair central nervous system biomaterial regenerative medicine nanotechnology spinal cord injury axonal regeneration exosome extracellular vesicle microRNA microvesicle nerve gap neurite outgrowth peripheral nerve injury Schwann cell stem cell hemodynamic phases cerebral subarachnoid hemorrhage metabolic crises nerve regeneration hypoxic-ischemic brain damage ginsenoside Rg1 neural stem cells cell transplantation cell differentiation cognition nerve reconstruction neural regeneration nerve regeneration brain injury neuroimaging functional magnetic resonance imaging regional homogeneity apoplexy subacute ischemia participants healthy volunteers brain activity NSFC grants neural regeneration nerve regeneration brain injury neuroprotection cerebral ischemia/reperfusion injury lateral intracerebroventricular injection Apelin-13 nerve apoptosis Bcl-2 caspase-3 NSFC grants neural regeneration nerve regeneration fractalkine CX3 chemokine receptor 1 neuronal maturation dendrites doublecortin synaptic maturation newborn neurons neural regeneration nerve regeneration neurodegenerative diseases Alzheimer′s disease transgenic animal models mice epimedium herb milkvetch root kudzuvine root divalent metal transporter 1 ferroportin 1 neural regeneration |
author_facet |
Xian-hui Dong Jiang-tao Bai Wei-na Kong Xiao-ping He Peng Yan Tie-mei Shao Wen-guo Yu Xi-qing Chai Yan-hua Wu Cong LIu |
author_sort |
Xian-hui Dong |
title |
Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload |
title_short |
Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload |
title_full |
Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload |
title_fullStr |
Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload |
title_full_unstemmed |
Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload |
title_sort |
effective components of chinese herbs reduce central nervous system function decline induced by iron overload |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 |
publishDate |
2015-01-01 |
description |
Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer′s disease patients. An APP swe/PS1ΔE9 double transgenic mouse model of Alzheimer′s disease was used. The intragastric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer′s disease. These compounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer′s disease. |
topic |
active zone stability Drosophila neuromuscular junction dephosphorylation Liprin-α Syd-1 PP2A GSK-3ß living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration injury plasticity neurodegenerative disease brain therapy neuron microglia neural progenitor tissue engineering neuroregeneration repair central nervous system biomaterial regenerative medicine nanotechnology spinal cord injury axonal regeneration exosome extracellular vesicle microRNA microvesicle nerve gap neurite outgrowth peripheral nerve injury Schwann cell stem cell hemodynamic phases cerebral subarachnoid hemorrhage metabolic crises nerve regeneration hypoxic-ischemic brain damage ginsenoside Rg1 neural stem cells cell transplantation cell differentiation cognition nerve reconstruction neural regeneration nerve regeneration brain injury neuroimaging functional magnetic resonance imaging regional homogeneity apoplexy subacute ischemia participants healthy volunteers brain activity NSFC grants neural regeneration nerve regeneration brain injury neuroprotection cerebral ischemia/reperfusion injury lateral intracerebroventricular injection Apelin-13 nerve apoptosis Bcl-2 caspase-3 NSFC grants neural regeneration nerve regeneration fractalkine CX3 chemokine receptor 1 neuronal maturation dendrites doublecortin synaptic maturation newborn neurons neural regeneration nerve regeneration neurodegenerative diseases Alzheimer′s disease transgenic animal models mice epimedium herb milkvetch root kudzuvine root divalent metal transporter 1 ferroportin 1 neural regeneration |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=778;epage=785;aulast=Dong |
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