Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload

Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expres...

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Main Authors: Xian-hui Dong, Jiang-tao Bai, Wei-na Kong, Xiao-ping He, Peng Yan, Tie-mei Shao, Wen-guo Yu, Xi-qing Chai, Yan-hua Wu, Cong LIu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Neural Regeneration Research
Subjects:
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=778;epage=785;aulast=Dong
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spelling doaj-b0d2f7679b0446c39210399d4b06b22c2020-11-25T04:00:11ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110577878510.4103/1673-5374.156981Effective components of Chinese herbs reduce central nervous system function decline induced by iron overloadXian-hui DongJiang-tao BaiWei-na KongXiao-ping HePeng YanTie-mei ShaoWen-guo YuXi-qing ChaiYan-hua WuCong LIuAbnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer′s disease patients. An APP swe/PS1ΔE9 double transgenic mouse model of Alzheimer′s disease was used. The intragastric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer′s disease. These compounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer′s disease.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=778;epage=785;aulast=Dongactive zone stabilityDrosophilaneuromuscular junctiondephosphorylationLiprin-αSyd-1PP2AGSK-3ßliving scaffoldsneural tissue engineeringcell transplantbiomaterialsregenerationneurotraumaneurodegenerationaxon pathfindingcell migrationinjuryplasticityneurodegenerative diseasebraintherapyneuronmicroglianeural progenitortissue engineeringneuroregenerationrepaircentral nervous systembiomaterialregenerative medicinenanotechnologyspinal cord injuryaxonal regenerationexosomeextracellular vesiclemicroRNAmicrovesiclenerve gapneurite outgrowthperipheral nerve injurySchwann cellstem cellhemodynamic phasescerebral subarachnoid hemorrhagemetabolic crisesnerve regenerationhypoxic-ischemic brain damageginsenoside Rg1neural stem cellscell transplantationcell differentiationcognitionnerve reconstructionneural regenerationnerve regenerationbrain injuryneuroimagingfunctional magnetic resonance imagingregional homogeneityapoplexysubacuteischemiaparticipantshealthyvolunteersbrain activityNSFC grantsneural regenerationnerve regenerationbrain injuryneuroprotectioncerebral ischemia/reperfusion injurylateral intracerebroventricular injectionApelin-13nerve apoptosisBcl-2caspase-3NSFC grantsneural regenerationnerve regenerationfractalkineCX3 chemokine receptor 1neuronal maturationdendritesdoublecortinsynaptic maturationnewborn neuronsneural regenerationnerve regenerationneurodegenerative diseasesAlzheimer′s diseasetransgenic animal modelsmiceepimedium herbmilkvetch rootkudzuvine rootdivalent metal transporter 1ferroportin 1neural regeneration
collection DOAJ
language English
format Article
sources DOAJ
author Xian-hui Dong
Jiang-tao Bai
Wei-na Kong
Xiao-ping He
Peng Yan
Tie-mei Shao
Wen-guo Yu
Xi-qing Chai
Yan-hua Wu
Cong LIu
spellingShingle Xian-hui Dong
Jiang-tao Bai
Wei-na Kong
Xiao-ping He
Peng Yan
Tie-mei Shao
Wen-guo Yu
Xi-qing Chai
Yan-hua Wu
Cong LIu
Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload
Neural Regeneration Research
active zone stability
Drosophila
neuromuscular junction
dephosphorylation
Liprin-α
Syd-1
PP2A
GSK-3ß
living scaffolds
neural tissue engineering
cell transplant
biomaterials
regeneration
neurotrauma
neurodegeneration
axon pathfinding
cell migration
injury
plasticity
neurodegenerative disease
brain
therapy
neuron
microglia
neural progenitor
tissue engineering
neuroregeneration
repair
central nervous system
biomaterial
regenerative medicine
nanotechnology
spinal cord injury
axonal regeneration
exosome
extracellular vesicle
microRNA
microvesicle
nerve gap
neurite outgrowth
peripheral nerve injury
Schwann cell
stem cell
hemodynamic phases
cerebral subarachnoid hemorrhage
metabolic crises
nerve regeneration
hypoxic-ischemic brain damage
ginsenoside Rg1
neural stem cells
cell transplantation
cell differentiation
cognition
nerve reconstruction
neural regeneration
nerve regeneration
brain injury
neuroimaging
functional magnetic resonance imaging
regional homogeneity
apoplexy
subacute
ischemia
participants
healthy
volunteers
brain activity
NSFC grants
neural regeneration
nerve regeneration
brain injury
neuroprotection
cerebral ischemia/reperfusion injury
lateral intracerebroventricular injection
Apelin-13
nerve apoptosis
Bcl-2
caspase-3
NSFC grants
neural regeneration
nerve regeneration
fractalkine
CX3 chemokine receptor 1
neuronal maturation
dendrites
doublecortin
synaptic maturation
newborn neurons
neural regeneration
nerve regeneration
neurodegenerative diseases
Alzheimer′s disease
transgenic animal models
mice
epimedium herb
milkvetch root
kudzuvine root
divalent metal transporter 1
ferroportin 1
neural regeneration
author_facet Xian-hui Dong
Jiang-tao Bai
Wei-na Kong
Xiao-ping He
Peng Yan
Tie-mei Shao
Wen-guo Yu
Xi-qing Chai
Yan-hua Wu
Cong LIu
author_sort Xian-hui Dong
title Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload
title_short Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload
title_full Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload
title_fullStr Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload
title_full_unstemmed Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload
title_sort effective components of chinese herbs reduce central nervous system function decline induced by iron overload
publisher Wolters Kluwer Medknow Publications
series Neural Regeneration Research
issn 1673-5374
publishDate 2015-01-01
description Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer′s disease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer′s disease patients. An APP swe/PS1ΔE9 double transgenic mouse model of Alzheimer′s disease was used. The intragastric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer′s disease. These compounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer′s disease.
topic active zone stability
Drosophila
neuromuscular junction
dephosphorylation
Liprin-α
Syd-1
PP2A
GSK-3ß
living scaffolds
neural tissue engineering
cell transplant
biomaterials
regeneration
neurotrauma
neurodegeneration
axon pathfinding
cell migration
injury
plasticity
neurodegenerative disease
brain
therapy
neuron
microglia
neural progenitor
tissue engineering
neuroregeneration
repair
central nervous system
biomaterial
regenerative medicine
nanotechnology
spinal cord injury
axonal regeneration
exosome
extracellular vesicle
microRNA
microvesicle
nerve gap
neurite outgrowth
peripheral nerve injury
Schwann cell
stem cell
hemodynamic phases
cerebral subarachnoid hemorrhage
metabolic crises
nerve regeneration
hypoxic-ischemic brain damage
ginsenoside Rg1
neural stem cells
cell transplantation
cell differentiation
cognition
nerve reconstruction
neural regeneration
nerve regeneration
brain injury
neuroimaging
functional magnetic resonance imaging
regional homogeneity
apoplexy
subacute
ischemia
participants
healthy
volunteers
brain activity
NSFC grants
neural regeneration
nerve regeneration
brain injury
neuroprotection
cerebral ischemia/reperfusion injury
lateral intracerebroventricular injection
Apelin-13
nerve apoptosis
Bcl-2
caspase-3
NSFC grants
neural regeneration
nerve regeneration
fractalkine
CX3 chemokine receptor 1
neuronal maturation
dendrites
doublecortin
synaptic maturation
newborn neurons
neural regeneration
nerve regeneration
neurodegenerative diseases
Alzheimer′s disease
transgenic animal models
mice
epimedium herb
milkvetch root
kudzuvine root
divalent metal transporter 1
ferroportin 1
neural regeneration
url http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=5;spage=778;epage=785;aulast=Dong
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