| Summary: | Background: Early diagnosis and management of intra medullary spinal cord lesions is crucial for improving the outcome. This can be achieved by adding DW-MRI to spinal imaging protocol. Patients & methods: A prospective study included 42 patients proved to have intramedullary SOLs of non-traumatic causes based on cMRI, were subjected to DWI and ADC value measurement. Our findings were correlated to the clinical outcome in non-neoplastic lesions and o the histopathological results in neoplastic lesions. Results: 20 cases of non-neoplastic lesions (group I) showed nonrestricted diffusion with variable increased ADC values (mean = 1.46 ± 0.35 × 103 mm2/s), except in cord acute ischemia which had restricted diffusion and reduced ADC value (mean = 0.85 ± 0.07 × 103 mm2/s). 22 cases of neoplastic lesions (group II) showed reduced ADC values (mean 1.05 ± 0.21 × 103 mm2/s), the lowest was in metastatic lesions (mean 0.75 ± 0.15 × 103 mm2/s) and medulloblastoma (mean 0.81 ± 0.09 × 103 mm2/s) while a diagnostic overlap occurred between astrocytoma and ependymoma (mean 1.19 ± 0.07, 1.1 ± 0.07 × 103 mm2/s respectively). A cut off value 1.25 × 103 mm2/s was found to differentiate between the two groups. Conclusion: Optimum diagnosis for non-traumatic intra-medullary spinal cord lesions can be achieved by using DWI and ADC value measurement. Keywords: MR-DWI, ADC value, Non traumatic, Intramedullary lesions
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