Predicting TCR-Epitope Binding Specificity Using Deep Metric Learning and Multimodal Learning

Predicting TCR-Epitope Binding Specificity Using Deep Metric Learning and Multimodal Learning

Understanding the recognition of specific epitopes by cytotoxic T cells is a central problem in immunology. Although predicting binding between peptides and the class I Major Histocompatibility Complex (MHC) has had success, predicting interactions between T cell receptors (TCRs) and MHC class I-pep...

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Bibliographic Details
Main Authors: Alan M. Luu, Jacob R. Leistico, Tim Miller, Somang Kim, Jun S. Song
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
T cell receptors
epitope binding specificity
deep learning
metric learning
multimodal learning
Online Access:https://www.mdpi.com/2073-4425/12/4/572

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