The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease

The Induction of Alpha-1 Antitrypsin by Vitamin D in Human T Cells Is TGF-β Dependent: A Proposed Anti-inflammatory Role in Airway Disease

Background: Vitamin D upregulates anti-inflammatory and antimicrobial pathways that promote respiratory health. Vitamin D synthesis is initiated following skin exposure to sunlight, however nutritional supplementation can be required to address deficiency, for example during the winter months or due...

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Bibliographic Details
Main Authors: Yin-Huai Chen, Charlotte E. Cheadle, Louise V. Rice, Paul E. Pfeffer, Sarah Dimeloe, Atul Gupta, Andrew Bush, Bibek Gooptu, Catherine M. Hawrylowicz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Nutrition
Subjects:
vitamin D
T cell
alpha-1 antitrypsin (AAT)
anti-inflammatory
HBEC
airway disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2021.667203/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2021.667203/full

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