Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance

Abstract Myostatin is a negative regulator of muscle mass and its inhibition represents a promising strategy for the treatment of muscle disorders and type 2 diabetes. However, there is currently no clinically effective myostatin inhibitor, and therefore novel methods are required. We evaluated the...

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Bibliographic Details
Main Authors: Wouter Eilers, Mark Cleasby, Keith Foster
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81222-7