Secretory phospholipase A2 type III enhances α-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity

Secretory phospholipase A2 type III enhances α-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity

In the non-amyloidogenic pathway, amyloid precursor protein (APP) is cleaved by α-secretases to produce α-secretase-cleaved soluble APP (sAPPα) with neuroprotective and neurotrophic properties; therefore, enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological appro...

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Bibliographic Details
Main Authors: Xiaoguang Yang, Wenwen Sheng, Yan He, Jiankun Cui, Mark A. Haidekker, Grace Y. Sun, James C-M. Lee
Format: Article
Language:English
Published: Elsevier 2010-05-01
Series:Journal of Lipid Research
Subjects:
arachidonic acid
amyloid-β peptide
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520410508

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http://www.sciencedirect.com/science/article/pii/S0022227520410508

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