Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress

Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress

Recently, we showed that oxidative stress activates the expression and activity of the β-site AβPP-cleaving enzyme (BACE), an aspartyl protease responsible for the β-secretase cleavage of AβPP. The identification of compounds able to prevent the induction of this event is an important goal of therap...

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Bibliographic Details
Main Authors: E Tamagno, M Guglielmotto, P Bardini, G Santoro, A Davit, D Di Simone, O Danni, M Tabaton
Format: Article
Language:English
Published: Elsevier 2003-11-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
DHEA
BACE
Oxidative stress
Antioxidants
NT2 neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001311

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