Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4.

G protein coupled receptors (GPCRs) allow for the transmission of signals across biological membranes. For a number of GPCRs, this signaling was shown to be coupled to prior dimerization of the receptor. The chemokine receptor type 4 (CXCR4) was reported before to form dimers and their functionality...

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Bibliographic Details
Main Authors: Kristyna Pluhackova, Stefan Gahbauer, Franziska Kranz, Tsjerk A Wassenaar, Rainer A Böckmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-11-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5094716?pdf=render