Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The ana...

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Main Authors:	Rocco Vitalone, Paolo Luciano, Concetta Imperatore, Ernesto Fattorusso, Filomena D'Aniello, Anna Aiello, Marialuisa Menna
Format:	Article
Language:	English
Published:	MDPI AG 2012-11-01
Series:	Marine Drugs
Subjects:	natural products sponges Axinellidae pyrrole-imidazole alkaloids taxon-specificity
Online Access:	http://www.mdpi.com/1660-3397/10/11/2509

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spelling	doaj-b0a88b7742bc41fc9a72d22d35a300012020-11-24T23:14:11ZengMDPI AGMarine Drugs1660-33972012-11-0110112509251810.3390/md10112509Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New BetaineRocco VitalonePaolo LucianoConcetta ImperatoreErnesto FattorussoFilomena D'AnielloAnna AielloMarialuisa MennaAn exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.http://www.mdpi.com/1660-3397/10/11/2509natural productsspongesAxinellidaepyrrole-imidazole alkaloidstaxon-specificity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rocco Vitalone Paolo Luciano Concetta Imperatore Ernesto Fattorusso Filomena D'Aniello Anna Aiello Marialuisa Menna
spellingShingle	Rocco Vitalone Paolo Luciano Concetta Imperatore Ernesto Fattorusso Filomena D'Aniello Anna Aiello Marialuisa Menna Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine Marine Drugs natural products sponges Axinellidae pyrrole-imidazole alkaloids taxon-specificity
author_facet	Rocco Vitalone Paolo Luciano Concetta Imperatore Ernesto Fattorusso Filomena D'Aniello Anna Aiello Marialuisa Menna
author_sort	Rocco Vitalone
title	Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_short	Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_full	Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_fullStr	Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_full_unstemmed	Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine
title_sort	further investigation of the mediterranean sponge axinella polypoides: isolation of a new cyclonucleoside and a new betaine
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2012-11-01
description	An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.
topic	natural products sponges Axinellidae pyrrole-imidazole alkaloids taxon-specificity
url	http://www.mdpi.com/1660-3397/10/11/2509
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Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

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