Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

Further Investigation of the Mediterranean Sponge Axinella polypoides: Isolation of a New Cyclonucleoside and a New Betaine

An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The ana...

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Bibliographic Details
Main Authors: Rocco Vitalone, Paolo Luciano, Concetta Imperatore, Ernesto Fattorusso, Filomena D'Aniello, Anna Aiello, Marialuisa Menna
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Marine Drugs
Subjects:
natural products
sponges
Axinellidae
pyrrole-imidazole alkaloids
taxon-specificity
Online Access:http://www.mdpi.com/1660-3397/10/11/2509
Description
Summary:An exhaustive exploration into the metabolic content of the Mediterranean sponge Axinella-polypoides resulted in the isolation of the new betaine 5 and the new cyclonucleoside 8. The structures of the new metabolites were elucidated by spectroscopic methods assisted by computational methods. The analysis also provided evidence that the sponge does not elaborate pyrrole-imidazole alkaloids (PIAs) but, interestingly, it was shown to contain two already known cyclodipeptides, compounds 9 (verpacamide A) and 10.
ISSN:1660-3397

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