β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

Previously, we showed that a hierarchy of spectrin cytoskeletal proteins maintains nodal Na+ channels (Liu et al., 2020). Here, using mice lacking β1, β4, or β1/β4 spectrins, we show this hierarchy does not function at axon initial segments (AIS). Although β1 spectrin, together with AnkyrinR (AnkR),...

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Bibliographic Details
Main Authors: Cheng-Hsin Liu, Ryan Seo, Tammy Szu-Yu Ho, Michael Stankewich, Peter J Mohler, Thomas J Hund, Jeffrey L Noebels, Matthew N Rasband
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
axon
cytoskeleton
ion channels
Online Access:https://elifesciences.org/articles/56629

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