Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles

Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles

Circular dorsal ruffles (CDRs) are important for the vesicular uptake of extracellular matter, but the basis of their wave dynamics is not understood. Here, the authors propose and experimentally test a bistable reaction-diffusion system, which they show accounts for the typical CDR expansion and sh...

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Main Authors: Erik Bernitt, Hans-Günther Döbereiner, Nir S. Gov, Arik Yochelis
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15863
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spelling doaj-b0a7abdcb6774d989d06bfab761b2ebc2021-05-11T07:16:41ZengNature Publishing GroupNature Communications2041-17232017-06-01811810.1038/ncomms15863Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal rufflesErik Bernitt0Hans-Günther Döbereiner1Nir S. Gov2Arik Yochelis3Department of Chemical Physics, Weizmann Institute of ScienceInstitut für Biophysik, Universität BremenDepartment of Chemical Physics, Weizmann Institute of ScienceDepartment of Solar Energy and Environmental Physics, Swiss Institute for Dryland Environmental and Energy Research, Blaustein Institutes for Desert Research (BIDR), Ben-Gurion University of the NegevCircular dorsal ruffles (CDRs) are important for the vesicular uptake of extracellular matter, but the basis of their wave dynamics is not understood. Here, the authors propose and experimentally test a bistable reaction-diffusion system, which they show accounts for the typical CDR expansion and shrinkage and for aberrant formation of pinned waves and spirals.https://doi.org/10.1038/ncomms15863
collection DOAJ
language English
format Article
sources DOAJ
author Erik Bernitt
Hans-Günther Döbereiner
Nir S. Gov
Arik Yochelis
spellingShingle Erik Bernitt
Hans-Günther Döbereiner
Nir S. Gov
Arik Yochelis
Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
Nature Communications
author_facet Erik Bernitt
Hans-Günther Döbereiner
Nir S. Gov
Arik Yochelis
author_sort Erik Bernitt
title Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
title_short Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
title_full Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
title_fullStr Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
title_full_unstemmed Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
title_sort fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Circular dorsal ruffles (CDRs) are important for the vesicular uptake of extracellular matter, but the basis of their wave dynamics is not understood. Here, the authors propose and experimentally test a bistable reaction-diffusion system, which they show accounts for the typical CDR expansion and shrinkage and for aberrant formation of pinned waves and spirals.
url https://doi.org/10.1038/ncomms15863
work_keys_str_mv AT erikbernitt frontsandwavesofactinpolymerizationinabistabilitybasedmechanismofcirculardorsalruffles
AT hansguntherdobereiner frontsandwavesofactinpolymerizationinabistabilitybasedmechanismofcirculardorsalruffles
AT nirsgov frontsandwavesofactinpolymerizationinabistabilitybasedmechanismofcirculardorsalruffles
AT arikyochelis frontsandwavesofactinpolymerizationinabistabilitybasedmechanismofcirculardorsalruffles
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